Titolo originale: Antioxidant activity of the polyphenol Mangiferin di Ivanka Stoilova, Leopold Jirovetz, Albena Stoyanova, Albert Krastanov, Stoyanka Gargova, Lien Ho. Pharmacological Research 57 (2008) 332–338
The antioxidant properties of alcohol solutions of mangiferin were studied. The antioxidant activity in linoleic acid/water emulsion system, determined by the thiobarbituric acid reactive substances (TBARS), was higher at 37°C – 72.0%, and by inhibiting conjugated dienes formation – 70.4%. At 80°C the antioxidant activity at the highest concentration was less efficient: 67.2 % for conjugated dienes and 69.1% for TBARS. Mangiferin inhibited the hydroxyl radicals by 84.3% at 37°C and 79.8% at 80°C, as it showed a higher antioxidant activity than quercetine. The IC50 concentration for the inhibition of OH· at 37°C was lower than that at 80°C – 0.88 µg/ml and 1.81 µg/ml, respectively. Mangiferin chelated Fe3+ in the solution. The inhibiting effect of mangiferin with regard to the xanthine oxidase activity was weaker – 71.4%, as IC50 concentration for the reduction of nitroblue tetrazolium was 14.17 µg/ml.
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